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Manhattan townhouse with a rich history and presidential connections is set to list for $10.5 million. The 122 E. 38th St. property, located in Murray Hill, was once the home of Mary "Mamie" Lincoln Isham, granddaughter of Abraham Lincoln. Built in 1904 by architect Ralph S. Townsend, the six-bedroom townhouse boasts a cellar and a rare commercial-residential split.

    In 1906, Mamie and her husband Charles Isham purchased the property, which was later expanded with an attic for servants' quarters in 1913. Mamie lived there until 1935, after her husband's death in 1919. The townhouse changed hands again in 2012 when inventor James Jorasch bought it for $5.14 million, drawn by the Lincoln connection and Abraham Lincoln's unique status as the only US president with a patent.

    The property now serves as both Jorasch's home and his Science House consulting firm's headquarters, taking advantage of its rare mixed-use zoning. The 6,300-square-foot townhouse features original details like a grand staircase and one of Manhattan's earliest residential elevators, as well as a rooftop terrace with night views of the city.

    "It's very difficult to find a legal place to run a business in a townhouse," says Loy Carlos of Nest Seekers International. "This property is a dream spot for artsy types craving a gallery setup or live-work use." The property's narrow width and deep layout pack a surprising punch, with a spacious interior that belies its exterior appearance.

    The home still retains many original features, including moldings and a vintage elevator that Jorasch has souped up. Up top, the rooftop terrace offers a private space for entertaining, with night views of the Chrysler Building and Empire State Building.